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In my article: “Evolution of Microbial Quorum Sensing to Human Global Quorum Sensing: An Insight into How Gap Junctional Intercellular Communication Might Be Linked to the Global Metabolic Disease Crisis” 2, I attempted to integrate how the original single cell organism, living in an hostile environment, acquired genes to deal with an environment with no oxygen and a need to adapt to changing amounts of nutrients for individual life and the reproductive survival of its species. Its metabolic processes required genes that coded for enzymes needed to metabolize glucose, in the absence of oxygen, to produce energy from an inefficient process to make a couple ATP molecules (anaerobic glycolysis). In addition, to meet the demand that as a single cell, it had to acquire genes to be able to communicate with each other concerning the availability of nutrients. Without that ability to communicate with each other about the status of that nutrient pool, each cell would not change its individual need to consume the nutrients at the “normal” rate. It was the primordial means to communicate that emerged, namely the production of a secreted molecule that could be detected by other members of this population when the nutrient levels are being depleted that would signal all of them to slow down their metabolism. The concept of “quorum sensing” was created to depict this process3. If that means of communicating never occurred, the chances of both individual and species survival would be small.