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Alan Prem Kumar has completed PhD from University of North Texas, USA. He is currently an Assistant Professor at the National University of Singapore. He has over 150 publications that and his publication H-index is 36 and has been serving as an editorial board member of reputed Journals and established several industry collaborations.


Simvastatin, a lipophilic statin used for lowering cholesterol, inhibits 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme of the mevalonate pathway. Studies have shown that cancer cells express deregulated level of HMGCR and statins exert anti-tumoral activities. We first assessed correlation between mevalonate pathway genes and DDX20 (DP103, Gemin-3) in 1325 breast cancer patients and observed a positive correlation between DDX20 and the mevalonate pathway genes. Having this data, we then proceeded to explore the effect of statins on DDX20 expression. We used various in vitro cell lines and in vivo statin clinical trial patients’ specimens, mouse xenograft, mouse intravenous tail injection and Drosophila (wild-type vs Gemin-3 knockdown vs Gemin-3 overexpression flies) models. We show exposure to statin decreases the expression of DDX20. Through a series of add-back experiments, we show that the decrease in DDX20 expression by statins is via the mevalonate pathway and downstream of RhoA. In clinical specimens, we observed breast cancer patients with high baseline DDX20 positively correlates with high baseline YAP-TEAD expression. Having known that SUMOylation of YAP maintains its activity and that DDX20 is a critical enhancer of the SUMOlyation machinery, we showed through a series of experiments that a physical interaction between DDX20 and YAP is crucial for maintaining SUMOylation of YAP; thereby decreasing its ubiquitination and degradation. Interestingly, we also identified for the first time that DDX20 is a direct target of YAP-TEAD complex and that maintenance of DDX20 expression is needed as a positive feedback forming an Achilles heel for sustained YAP-TEAD activity.

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This cancellation policy was last updated on November 05, 2019.

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Cancellation Policy

If 3rd Global Expo on Cancer and Oncology Research Group cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Group event which must occur within one year from the date of cancellation.


If 3rd Global Expo on Cancer and Oncology Research Group postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Ltd event which must occur within one year from the date of postponement.

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All fully paid registrations are transferable to other persons from the same organization if the registered person is unable to attend the event. Transfers must be made by the registered person in writing to Details must be included the full name of replacement person, their title, contact phone number, and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies Ltd if the person is unable to attend one of the conferences.

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If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

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