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Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation President, The Buddhist Tzu Chi Bioinnovation Center Charter Fellow of National Academy of Inventor (USA) Fellow of American Association of Advancement of Science (USA) Fellow of American Institute for Medical and Biological Engineering (AIMBE) (USA)


Malignant brain glioma is a highly invasive disease with a very high death rate. The effective treatment method for this disease is still an unmet medical need. In our previous reports, a pure compound EF-001 showed activities to arrest the growth and initiate apoptosis of malignant brain glioma. To overcome the limitation of the blood-brain barrier, a local-release system with EF-001 incorporated into a biodegradable polyanhydride material, p(CPP-SA), was developed and named “Cerebraca Wafer”. Both the in vitro and the in vivo release kinetics of the Cerebraca Wafers have been characterized. The in situ therapeutic effects of the Cerebraca Wafer on brain gliomas were demonstrated by FGF-SV40 transgenic mice and orthotopic brain tumor F344 rat models. Significant effects on the inhibition of tumor growth and the increase of survival rate by Cerebraca Wafer implantations were observed, with no significant adverse effects on the rodents. Mechanisms involved in the antitumor effect of EF-001, downstream of AXL receptor tyrosine kinase, including the up-regulation of Nurr77 by PKC, the repression of human telomerase reverse transcriptase (hTERT) transcriptional activity via down-regulating Sp1 expression, and the down-regulation of the S-phase kinase-associated protein 2 (Skp2) which resulted in the brain tumor senescence, were also investigated in the study. The toxicity studies and the PIC/s GMP grade Cerebraca Wafer production for clinical trials were accomplished. IND (investigational New Drug) application for the Phase I/IIa clinical trials aiming to determine the safety and the efficacy of Cerebraca Wafer implantation on the recurrent GBM patients have been approved by USFDA and TFDA at 2016. The trial is now being performed at Hualien Tzu-Chi hospital and Tri-Service General hospital, with the first Wafer implantation surgery completed at the end of 2017. The preliminary results for the first three trial patients will be presented and discussed.

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This cancellation policy was last updated on November 05, 2019.

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Cancellation Policy

If 3rd Global Expo on Cancer and Oncology Research Group cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Group event which must occur within one year from the date of cancellation.


If 3rd Global Expo on Cancer and Oncology Research Group postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Ltd event which must occur within one year from the date of postponement.

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If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

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