Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences


Liang YC has completed his PhD at the age of 32 years from National Taiwan University, Taiwan. He is the professor of Taipei Medical University, Taiwan. He has over 100 publications that have been cited over 5000 times, and his publication H-index is 37.


ZFP36 family members include ZFP36 (also named TTP and TIS11), ZFP36L1 (also called BRF1, ERF1, or TIS11B), and ZFP36L2 (also called BRF2, ERF2, and TIS11D), which belong to CCCH-type zinc finger proteins with two tandem zinc finger (TZF) regions. TTP was found to induce cell senescence by promoting p53 protein expression. However, it is unclear whether ZFP36L1 and ZFP36L2 have antiproliferative activities similar to that of TTP. In this study, a tetracycline-inducible (Tet-On) system was used to induce the expression of ZFP36L1 or ZFP36L2 in T-REx-293 cells by doxycycline (Dox) treatment. Three human colorectal cancer cell lines, HCT116 p53+/+, HCT116 p53-/-, and SW620 (mutated p53) cells, were used to overexpress the wild-type or TZF mutation of ZFP36L1 or ZFP36L2 gene as well as to knockdown the ZFP36L1 or ZFP36L2 gene by lentiviral vectors. When ZFP36L1 or ZFP36L2 was overexpressed, we found that cell proliferation was dramatically inhibited, but did not cause significant cell death. The induction of ZFP36L1 or ZFP36L2 resulted in cell cycle arrest at the G1 phase and an increase in p53 expression. In contrast, levels of cell cycle-related proteins including cyclin B, cyclin D, cyclin A, and p21 decreased in ZFP36L1- or ZFP36L2-overexpressing T-REx-293 cells. Forced expression of ZFP36L1 or ZFP36L2 also inhibited cell proliferation and cyclin D gene expression in these three kinds of cells; however, it increased p53 and p21 expressions only in HCT116 p53+/+ cells. On the other hand, knockdown of ZFP36L1 or ZFP36L2 increased cell proliferation and cyclin D expression, and mutation of the TZF of ZFP36L1 (C135/173R) or ZFP36L2 (C174/212R) caused them to lose their antiproliferative ability, such that they could not inhibit cyclin D expression in these three cell lines. The results suggest that ZFP36L1 and ZFP36L2 play a negative role in cell proliferation of human colorectal cancer cells, and the underlying mechanisms might be mediated through a cyclin D-dependent and p53-independent pathway

Allied Academies Global Conference Directory

Mail us at

Abstract Submission/ Registration
Sponsor/ Exhibition/ Advertisement
General Query
More details about

Terms and Conditions


Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.


Registration fees do not include insurance of any kind.


Please note that any (or) all transportation and parking is the responsibility of the registrant.


Press permission must be obtained from 3rd Global Expo on Cancer and Oncology Research Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies Ltd is an objective third-party non-profit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact to request a personalized letter of invitation.

Regarding refunds, all bank charges will be for the registrant's account.

This cancellation policy was last updated on November 05, 2019.

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to

Cancellation Policy

If 3rd Global Expo on Cancer and Oncology Research Group cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Group event which must occur within one year from the date of cancellation.


If 3rd Global Expo on Cancer and Oncology Research Group postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Ltd event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization if the registered person is unable to attend the event. Transfers must be made by the registered person in writing to Details must be included the full name of replacement person, their title, contact phone number, and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies Ltd if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if it is intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies Ltd will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies Ltd, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 90 days of the conference: Eligible for Full Refund less $100 Service Fee

  • Within 90-60 days of Conference: Eligible for 50% of payment Refund

  • Within 60 days of Conference: Not eligible for Refund

  • E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

Authorization Policy

Copyright © 2020-2021 Allied Academies, All Rights Reserved.