Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences

Biography

TBA

Abstract

Introduction: Circulating tumor cells (CTCs) are considered as a “liquid biopsy” that allows the assessment of tumor changes over time. Tumor cells may escape from the immune system through, among others, the activation of PD-1/PD-L1 axis. Targeting these molecules with monoclonal antibodies has shown encouraging results at many types of cancers including NSCLC. In the current study we investigated the expression of PD-1/PD-L1 molecules on the CTCs isolated from NSCLC patients treated with Nivolumab. Methods: CTCs were isolated based on their size using the ISET platform from 27 patients treated with Nivolumab before treatment, after 1 cycle and after 3 cycles. CTCs were detected after staining with Giemsa and immunofluorescence (IF) double staining using either Cytokeratin (A45-B/B3) (CK7)/PD-1 or Cytokeratin (A45-B/B3)(CK7)//PD-L1 antibodies and analysis with the ARIOL system. Spiking experiments using the NSCLC H460, H1299, HCC827 and SKMES cell lines in normal blood were used to evaluate the detection method. Results: Giemsa evaluation in Nivolumab-treated patients at baseline (25 evaluable samples), after the 1st (9 evaluable samples) and after the 3rd (8 evaluable patients) cycle of treatment showed that CTCs could be detected in 48% (12/25), 33.3% (3/9) and 50% (4/8) of patients, respectively. IF could also reveal the presence of CK-positive cells in 48% (12/25), 22% (2/9) and 75% (6/8) patients, respectively. PD-1 (+) CTCs were detected in 33.3% (4/12) of patients at baseline, in, 0% after the 1 and 16.7% (1/6) of patients after the 3rd cycle whereas PD-L1(+) CTCs in 33.3% (4/12), 0% and 16.7% (1/6),patients, respectively. The expression of PD-1 at baseline was associated with poorer OS (p=0.022) and PFS (p=0.011), while the expression of PD-L1 was associated with shorter PFS (p=0.011). Multivariate analysis revealed that the presence of CK-positive cells is an independent prognostic factor for OS (p=0.028) Conclusion: CTCs from patients with NSCLC express PD-1 and PD-L1 molecules and their expression seems to be associated with the clinical outcome of patients treated with nivolumab.

Allied Academies Global Conference Directory

Mail us at

Abstract Submission/ Registration
info@conferencesmeet.com
Sponsor/ Exhibition/ Advertisement
info@conferencesmeet.com
General Query
info@conferencesmeet.com
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions

Responsibility

Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.

Insurance

Registration fees do not include insurance of any kind.

Transportation

Please note that any (or) all transportation and parking is the responsibility of the registrant.

Press/Media

Press permission must be obtained from 3rd Global Expo on Cancer and Oncology Research Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies Ltd is an objective third-party non-profit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact cancersummit@insightconferences.com to request a personalized letter of invitation.

Regarding refunds, all bank charges will be for the registrant's account.

This cancellation policy was last updated on November 05, 2019.

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to finance@alliedacademies.com

Cancellation Policy

If 3rd Global Expo on Cancer and Oncology Research Group cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Group event which must occur within one year from the date of cancellation.

Postponement

If 3rd Global Expo on Cancer and Oncology Research Group postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Ltd event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization if the registered person is unable to attend the event. Transfers must be made by the registered person in writing to finance@alliedacademies.com. Details must be included the full name of replacement person, their title, contact phone number, and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies Ltd if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if it is intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies Ltd will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies Ltd, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 90 days of the conference: Eligible for Full Refund less $100 Service Fee

  • Within 90-60 days of Conference: Eligible for 50% of payment Refund

  • Within 60 days of Conference: Not eligible for Refund

  • E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

Authorization Policy

Copyright © 2020-2021 Allied Academies, All Rights Reserved.